Abstract
G A A b st ra ct s of these patients had a normal response to multiple rapid swallow (MRS). Only 16% of the non-hypermobile patients with dysphagia had hypomotility (p<0.0005 vs JHS). 1 JHS patient (6%) had achalasia compared with 17% controls (p:0.24). 41% of the JHS patients had normal oesophageal motility and 6 of these had reflux studies: 50% had GORD. Only 2 JHS patients (12%) had hiatus hernias vs 20% in the control group (NS). Conclusion: This is the first study to characterise upper GI physiology in patients with JHS and non-obstructive dysphagia. Compared to dysphagia patients without hypermobility, the JHS patients had significantly more oesophageal hypomotility with half of them producing normal aftercontractions with MRS, suggesting muscle integrity. Those patients are likely to show the best response to prokinetics. The pathophysiology of hypomotility in these patients remains unknown. GORD was common in this population and will require antireflux therapy.
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