WGRLR: A Weighted Group Regularized Logistic Regression for Cancer Diagnosis and Gene Selection.

Abstract

Sparse regressions applied to cancer diagnosis suffer from noise reduction, gene grouping, and group significance evaluation. This paper presented the weighted group regularized logistic regression (WGRLR) for dealing with the above problems. Clean data was separated from noisy gene expression profile data, based on which gene grouping and model building were performed. An interpretable gene group significance evaluation criterion was proposed based on symmetrical uncertainty and module eigengene. A group-wise individual gene significance evaluation criterion was also presented. The performances of the proposed method were compared with WGGL, ASGL-CMI, SGL, GL, Elastic Net, and lasso on acute leukemia and brain cancer data. Experimental results demonstrate that the proposed method is superior to the other six methods in cancer diagnosis accuracy and gene selection.