Abstract
The structure of the title steroid [alternative name: 3β,6β-diacetoxy-5β-methyl-19-norcholest-9(10)-ene], C31H50O4, confirms the generally accepted mechanism for the rearrangement of a cholestan-5α-ol derivative reported a century ago by Westphalen. The methyl group at position 10 of the starting material migrates to position 5 in the steroidal nucleus, while a Δ9 bond is formed, as indicated by the C=C bond length of 1.347 (4) Å. The methyl transposition leaves the 5R configuration unchanged, with the methyl oriented towards the β face. During the rearrangement, the steroidal B ring experiences a conformational distortion from chair to envelope with the C atom at position 6 as the flap. In the title structure, the isopropyl group of the side chain is disordered over two positions, with occupancies of 0.733 (10) and 0.267 (10). The carbonyl O atom in the acetyl group at C3 is also disordered with an occupancy ratio of 0.62 (4):0.38 (4).
Highlights
Structure Reports OnlineJohana Ramırez Hernandez,a Jesus Sandoval-Ramırez,a Socorro Meza-Reyes,a Jose Luis Vega Baeza and Sylvain Bernesb*
The structure of the title steroid [alternative name: 3,6 diacetoxy-5 -methyl-19-norcholest-9(10)-ene], C31H50O4, confirms the generally accepted mechanism for the rearrangement of a cholestan-5 -ol derivative reported a century ago by Westphalen
The steroidal B ring experiences a conformational distortion from chair to envelope with the C atom at position 6 as the flap
Summary
Johana Ramırez Hernandez,a Jesus Sandoval-Ramırez,a Socorro Meza-Reyes,a Jose Luis Vega Baeza and Sylvain Bernesb*. The structure of the title steroid [alternative name: 3 ,6 diacetoxy-5 -methyl-19-norcholest-9(10)-ene], C31H50O4, confirms the generally accepted mechanism for the rearrangement of a cholestan-5 -ol derivative reported a century ago by Westphalen. The methyl group at position 10 of the starting material migrates to position 5 in the steroidal nucleus, while a Á9 bond is formed, as indicated by the C C bond length of 1.347 (4) A. The steroidal B ring experiences a conformational distortion from chair to envelope with the C atom at position 6 as the flap. The isopropyl group of the side chain is disordered over two positions, with occupancies of 0.733 (10) and 0.267 (10). The carbonyl O atom in the acetyl group at C3 is disordered with an occupancy ratio of 0.62 (4):0.38 (4)
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