Abstract
West Nile virus (WNV) is the most common domestic arbovirus in the United States. During 2018, WNV was transmitted through solid organ transplantation to 2 recipients who had neuroinvasive disease develop. Because of increased illness and death in transplant recipients, organ procurement organizations should consider screening during region-specific WNV transmission months.
Highlights
West Nile virus (WNV) is the most common domestic arbovirus in the United States
Less than 1% of the general population have neuroinvasive disease develop after being bitten by an infected mosquito
We found that patients infected by solid organ transplantation (SOT) have high rates of severe disease and death
Summary
West Nile virus (WNV) is the most common domestic arbovirus in the United States. During 2018, WNV was transmitted through solid organ transplantation to 2 recipients who had neuroinvasive disease develop. The case was reported to the United Network for Organ Sharing/ Organ Procurement and Transplantation Network for investigation by the ad hoc Disease Transmission Advisory Committee and subsequent referral to the Centers for Disease Control and Prevention (CDC). In organ donor’s state of residence, WNV human and equine disease cases, viremic blood donors, and mosquito infection rates were increased during 2018 compared with previous years.
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