Wernicke Encephalopathy in a Non-Alcoholic Patient With Metastatic CNS Lymphoma and New-Onset Occipital Lobe Seizures

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Back to table of contents Previous article Next article LettersFull AccessWernicke Encephalopathy in a Non-Alcoholic Patient With Metastatic CNS Lymphoma and New-Onset Occipital Lobe SeizuresJeremy Gregory, M.D., Kemuel Philbrick, M.D., and Amit Chopra, M.D.Jeremy GregorySearch for more papers by this author, M.D., Kemuel PhilbrickSearch for more papers by this author, M.D., and Amit ChopraSearch for more papers by this author, M.D.Published Online:1 Oct 2012https://doi.org/10.1176/appi.neuropsych.11110344AboutSectionsPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InEmail To the Editor: A 51-year-old man with no psychiatric or alcohol use history was treated for high-grade B-cell lymphoma involving the bowel, liver, and bone marrow, achieving complete remission with systemic chemotherapy. Six months later, he developed severe headaches secondary to relapsed CNS lymphoma.He presented with confusion, bilateral ophthalmoplegia, non-reactive pupils, and ptosis. MRI showed leptomeningeal enhancement along the temporal and occipital lobes bilaterally with adjacent parenchymal infiltration and expansion of the cavernous sinuses. On admission, high-dose intravenous methotrexate was initiated, and the psychiatry department was consulted because of concern for delirium. On mental status exam, he was noted to be confused, with florid visual hallucinations (seeing animals in his room, sparkles dancing on his skin, and the blood coursing through his veins).Wernicke encephalopathy (WE) was suspected, and, after one dose of intravenous thiamine, he became fully oriented, and his symptoms of ophthalmoplegia improved, but visual hallucinations persisted. EEG showed epileptogenic activity over the left occipital region consistent with simple partial occipital lobe seizures. Visual hallucinations resolved with initiation of levetiracetam.DiscussionThiamine deficiency leads to breakdown of the blood–brain barrier, neuronal necrosis, and irreversible brain damage in susceptible areas, including the medial thalamus and periaqueductal gray matter.1 Despite thiamine administration, WE patients (as high as 80%) may progress to Korsakoff syndrome, a chronic condition characterized by anterograde amnesia and confabulations.2 Coma and death may ensue, with 17% mortality for untreated WE.2The incidence of WE in the general cancer population is unknown. In one autopsy series, 8 of 24 patients with leukemia or lymphoma had pathologic findings suggestive of WE, none of which were recognized clinically.3,4 Cancer patients are at high risk of WE due to chronic malnutrition, chemotherapy-induced nausea and vomiting, and consumption of thiamine by rapidly-growing tumors such as hematological malignancies and sarcoma.1Brain MRI is the imaging procedure of choice5 because of high specificity (93%), although it cannot exclude WE because of low sensitivity (53%). MRI findings in alcoholic patients with acute WE may reveal atrophy of the mamillary bodies, infratentorial regions, supratentorial cortex, and corpus callosum, whereas atrophic changes are generally absent in nonalcoholic patients.5Diagnosis of WE is difficult in cancer patients because there are multiple reasons for confusional states, including hypoxia, infection, electrolyte imbalances, organ failure, opioid and sedative medications, chemotherapy, and brain and meningeal metastases.1 WE is a neurological emergency, and thiamine (500 mg 3 times daily) should be initiated immediately, either intravenously or intramuscularly, to ensure adequate absorption.4ConclusionsCancer patients are at high risk of developing WE, and it should be urgently treated with parenteral thiamine to prevent permanent neurologic damage and death. Thiamine prophylaxis should be considered in cancer patients to prevent WE.Dept. of Neurology, Mayo Clinic, Rochester, MNDept. of Psychiatry and Psychology, Mayo Clinic, Rochester, MNCorrespondence: chopra.[email protected]eduReferences1 Kuo SH, Debnam JM, Fuller GN, et al.: Wernicke’s encephalopathy: an underrecognized and reversible cause of confusional state in cancer patients. Oncology 2009; 76:10–18Crossref, Medline, Google Scholar2 Victor M, Adams RD, Collins GH: The Wernicke-Korsakoff syndrome. A clinical and pathological study of 245 patients, 82 with post-mortem examinations. Contemp Neurol Ser 1971; 7:1–206Medline, Google Scholar3 De Reuck J, Sieben G, De Coster W, et al.: Prospective neuropathologic study on the occurrence of Wernicke’s encephalopathy in patients with tumours of the lymphoid-hemopoietic systems. Acta Neuropathol Suppl 1981; 7:356–358Crossref, Medline, Google Scholar4 Fernandez M, Barceló M, Muñoz C, et al.: Anaphylaxis to thiamine (vitamin B1). Allergy 1997; 52:958–960Crossref, Medline, Google Scholar5 Antunez E, Estruch R, Cardenal C, et al.: Usefulness of CT and MR imaging in the diagnosis of acute Wernicke’s encephalopathy. AJR Am J Roentgenol 1998; 171:1131–1137Crossref, Medline, Google Scholar FiguresReferencesCited byDetailsCited byEpileptic seizures in nonalcoholic Wernicke’s encephalopathy: a case report and literature review6 September 2017 | Metabolic Brain Disease, Vol. 32, No. 6Wernicke encephalopathy as initial presentation of lymphomaThe Korean Journal of Internal Medicine, Vol. 32, No. 6Supportive Care in Cancer, Vol. 24, No. 1Neuro-Oncology Practice, Vol. 3, No. 3 Volume 24Issue 4 Fall 2012Pages E53-E53 Metrics PDF download History Published online 1 October 2012 Published in print 1 October 2012