Well-Ordered Mesoporous Silica Nanoparticles as a Recoverable Catalyst for One-Pot Multicomponent Synthesis of 4H-Chromene Derivatives

Abstract

A simple, efficient, and environmentally benign protocol for the synthesis of 4 H -chromene derivatives was developed using bio-compatible, neutral, and recoverable mesoporous silica nanoparticles as a catalyst. The 4 H -chromene derivatives were obtained in excellent yields by three component reaction of an aldehyde or isatin, malononitrile, and cyclic 1,3-diketones in ethanol at 60 °C. Synthesis of 4 H- chromenes by three component condensation of aldehydes or isatines, malononitrile, and cyclic 1,3-diketones was performed using mesoporous silica nanoparticles as a reusable catalyst.