Abstract
Well-differentiated pediatric glial neoplasms with features of oligodendroglioma, angiocentric glioma and dysembryoplastic neuroepithelial tumors: a morphological diagnostic challenge
Highlights
Classification of some pediatric primary central nervous system tumors can be challenging on the basis of routine histology and immunohistochemistry
All patients were alive with disease with a mean follow-up of 112 months. These four cases illustrate the morphological diversity of well-differentiated, oligodendroglioma-like glial neoplasms and the uncertainty in their classification among pediatric tumors
The diagnosis is often aided by the presence of secondary histological structures of Scherer, combined losses in chromosome 1p and 19q, and mutations in the either IDH-1 or the IDH-2 gene
Summary
Classification of some pediatric primary central nervous system tumors can be challenging on the basis of routine histology and immunohistochemistry. While OD is considered a tumor of adults, rare reports identify tumors with similar features in the pediatric population. Many studies on OD included patients younger than 15 years, but only a few studies analyzed pediatric OD exclusively. Such studies present some evidence that the biology of these tumors may be different from their adult counterparts. Another study demonstrated a much higher survival probability of pediatric oligodendrogliomas compared to adults [3]. Pediatric ODs reported to date seem to lack the typical molecular and clinical features of adult ODs, and the distinction from other well-differentiated tumors such as dysembryoplastic neuroepithelial tumor (DNT) may be extremely difficult [4]
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