Abstract
Horses have a well-developed mucosal-associated lymphoid tissue in the naso-oropharynx for immunological defence and the development of immunological tolerance. The different components of this lymphoid tissue have been documented, but not all areas of the equine oral cavity have been investigated. In the present study, samples for histological and immunohistochemical examinations were collected from slaughtered horses of different ages, focusing on the rostral part of the oral cavity. Dense lymphatic tissue was found in the mucosa covering the bar area of the mandibles and the floor of the oral cavity, and it was present in horses of different ages. The most prominent lymphatic tissue, with large aggregates of lymph nodules, was present on either side of the lingual frenulum. The rostral location of this lymphatic tissue in horses renders support for application of antigens in allergen-specific immunotherapy via the oral mucosa.
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