Abstract
Type 2 diabetes mellitus (T2DM) considered as one of the cardiovascular disorders (CVD) principle risk factor as diabetes is associated with abnormal levels of endothelial function, inflammatory and adipocytokines. The aim of this study was to measure the impact of weight reducing on inflammatory cytokines, adipocytokines and endothelial function biomarkers among obese T2DM patients. One-hundred T2DM patients enrolled in the present study; the age range was 35-55 year. Participants shared in this study were enrolled in group (A) received diet control and aerobic exercise on treadmill, while, group (B) had no intervention for 3 months. The mean values of body mass index (BMI), tumor necrosis factor -alpha (TNF-α), interleukin-6 (IL-6), leptin, inter-cellular adhesion molecule (ICAM-1), vascular cell adhesion molecule (VCAM-1), E-selectin and plasminogen activator inhibitor-1 activity (PAI-1 activity) were significantly decreased and adiponectin was increased significantly in the training group, however the results of the control group were not significant. Also, there were significant differences between both groups at the end of the study. Weight reducing program modulates inflammatory cytokines, adipocytokines and endothelial function biomarkers among obese T2DM patients.
Highlights
Type 2 diabetes mellitus (T2DM) is one of the cardiovascular disorders (CVD) principle risk factor 1-3, the risk of coronary artery disease is 2-4 times among patients with diabetes than non-diabetic subjects and peripheral vascular diseases risk is 10 times higher in diabetics than non-diabetics 4-5
Non-insulin dependent diabetes usually associated with several CVD and other body systems which are related to impaired endothelial function . 13-17 Increased level of systemic inflammation markers and decreased plasma adiponectin promote endothelial dysfunction which could be considered as an important pathogenic factors and potential triggers for cardiovascular disorders, insulin resistance and atherosclerosis in T2DM patients[18,19]
Weight reducing program is the key for management of obesity . 31-33 The principle results of the present study proved that weight loss ameliorated inflammatory cytokines (TNF-α, IL-6 and leptin) and endothelial function markers (ICAM-1 VCAM-1, E-selectin and plasminogen activator inhibitor-1 (PAI-1) activity) as well as improvement in adiponectin in T2DM patients, these findings agreed with Cotie et al . found that four months of weight reduction program modulated endothelial function and IL-6 34
Summary
Type 2 diabetes mellitus (T2DM) is one of the cardiovascular disorders (CVD) principle risk factor 1-3, the risk of coronary artery disease is 2-4 times among patients with diabetes than non-diabetic subjects and peripheral vascular diseases risk is 10 times higher in diabetics than non-diabetics 4-5. Weight reducing program composed of diet control and exercises associated with good prognosis as it modulated atherosclerosis and inflammatory biomarkers in T2DM patients . The study aimed to determine the impact of 12 weeks of weight reducing program on inflammatory cytokines, adipokines and endothelial function in obese T2DM patients. Type 2 diabetes mellitus (T2DM) considered as one of the cardiovascular disorders (CVD) principle risk factor as diabetes is associated with abnormal levels of endothelial function, inflammatory and adipocytokines. Objective: The aim of this study was to measure the impact of weight reducing on inflammatory cytokines, adipocytokines and endothelial function biomarkers among obese T2DM patients. Conclusion: Weight reducing program modulates inflammatory cytokines, adipocytokines and endothelial function biomarkers among obese T2DM patients.
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