Abstract
Weight Reduction Aids Antiepileptic Therapy to Restore Ovarian Functions of Epileptic Polycystic Ovary Women
Highlights
Epilepsy is a major public health problem in all countries
In epileptic PCOS women when polytherapy was provided with avoidance of VPA, combined weight reduction regimens associated with aerobic physical exercise intervention induce weight loss with subsequent amelioration of inhibitory effect of obesity on the reproductive function and adjustment of the hyperandrogenic milieu and induction of ovulatory cycles that promise for regaining fertility
A direct influence of epilepsy on the reproductive endocrine system is suggested by acute changes in PRL and gonadotropin levels following generalized and partial seizures, pointing to a possible relationship between temporolimbic epileptiform discharges and particular reproductive endocrine disorders
Summary
Epilepsy is a major public health problem in all countries. It has a strong personal, familial, and social impact, and in addition to seizures, patients and their families may have to face many other problems. Brain controls reproductive function primarily through hypothalamic regulation of pituitary secretion regions of the hypothalamus. These are areas receive extensive direct connections from the cerebral hemispheres, especially from temporolimbic structures, most notably of women with epilepsy with increased frequency of reproductive from the amygdala, that are commonly involved in temporal lobe endocrine disorders, in particular of polycystic ovary syndrome [1].
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