Weight-Reducing Effect of Lactobacillus plantarum ZJUFT17 Isolated from Sourdough Ecosystem.

Tongjie Liu,Fengqin Feng,Yang Li,Minjie Zhao,Qiufen Mo

doi:10.3390/nu12040977

Abstract

Lactobacillus plantarum ZJUFT17 (T17) is a potential probiotic bacterium isolated from Chinese traditional sourdough. The purpose of this study was to investigate its weight-reducing effects in mice fed a high-fat diet (HFD) and further to elucidate possible mechanisms. Male C57BL/6J mice fed HFD were given T17 (2–4 × 108 cfu) intragastrically for 10 weeks. The results showed that the administration of T17 significantly suppressed HFD-induced body weight gain, alleviated HFD-induced increase in serum lipids and decreased energy intake. The serum levels of obesity-related metabolic signaling molecules, including insulin, adiponectin, lipopolysaccharide (LPS) and the cytokines interleukin (IL)-1β and tumor necrosis factor (TNF)-α, were markedly improved. The 16S rRNA gene sequencing revealed that T17 administration dramatically modulated the gut microbiota, suppressing pathogenic and pro-inflammatory microbes and stimulating the microbes favoring anti-obesity. The weight-reducing efficacy of T17 may be explained by its ability to ameliorate systemic inflammation and insulin resistance mediated by gut microbiota. This study revealed that T17 could ameliorate obesity and the concomitant metabolic syndrome in mice and that the lactic acid bacteria in the sourdough ecosystem may also possess anti-obesity/weight-reducing properties.

Highlights

Obesity is a pathological state characterized by abnormal or excessive fat accumulation, owing to a chronic imbalance between energy intake and energy expenditure [1]
It was worth noting that body weight difference between the high-fat diet (HFD) and HFT groups occurred after 7 weeks of treatment and the HFT group showed a significantly lower body weight gain compared with the HFD group after the 10-week treatment
The results of our study showed that the administration of T17 led to a different composition in the gut microbiota compared with the mice in HFD and NCD groups, which confirmed the effect of T17 on gut microbiota modulation, as reported in our previous research [20]

Summary

Introduction

Obesity is a pathological state characterized by abnormal or excessive fat accumulation, owing to a chronic imbalance between energy intake and energy expenditure [1]. It is a known risk factor for the development of a series of diseases, such as metabolic syndrome, type II diabetes, hypertension, hypercholesterolemia, cardiovascular disease, and some forms of cancer [2,3]. What needs to be emphasized is that an energy imbalance between calorie intake and expenditure is the fundamental cause of overweight and obesity, and globally, an increased consumption of energy-dense foods that contain high fat and sugar contents and a decrease in physical activity facilitates the prevalence of obesity [4]

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