Weight loss improves serum mediators and metabolic syndrome features in android obese subjects

Abstract

Serum anti-/pro-inflammatory molecules such as adiponectin, IL-6, IL-10, and TNF-α, and metabolic syndrome (Met Syn) features in 15 android obese (6 Met Syn and 9 non-Met Syn) subjects were assessed during an 8-week weight control program. The results showed that the body mass index, weight, lean body mass, triglyceride, total cholesterol/high density lipoprotein cholesterol ratio, and TNF-α in Met Syn subjects were significantly (P < 0.05) improved. This study suggests that weight reduction in android obese subjects may be beneficial in reducing cardiovascular diseases via improving serum IL-6 and TNF-α levels, as well as Met Syn features.