Weight Loss among Adults with Type 2 Diabetes Participating in the Diabetes Prevention Program

Abstract

Evidence suggests substantial weight loss may be associated with remission of T2DM. We assessed weight loss in adults with T2DM participating in an intensive lifestyle intervention using the National Diabetes Prevention Program (DPP) curriculum. While enrollment was targeted toward adults at high-risk for T2DM, adults with T2DM who were referred by their primary care provider and received medical clearance to participate were also permitted to enroll in the DPP (N = 105). Seventy percent of these participants were female; the mean age and baseline BMI were 59.2 years (SD 8.9) and 38.7 kg/m2 (SD 7.7), respectively. The mean number of core sessions and total sessions (22 total sessions) completed by participants was 12.1 (SD 3.8) and 14.5 (SD 5.5). Sixty percent of participants achieved the physical activity goal of ≥150 minutes of moderate physical activity. Forty-six percent and 28% of participants achieved ≥5% and ≥7% weight loss respectively. Results from the multiple logistic regression models indicated that participants who self-monitored their fat intake consistently and met the physical activity goal were more likely to achieve the 7% weight loss goal and participants who self-monitored their fat intake consistently were more likely to achieve ≥5% weight loss (Table). Our findings suggest that many persons with T2DM can achieve substantial weight loss through participation in DPP lifestyle intervention.Table. Factors independently associated with achieving seven percent and five percent weight loss among participants with T2DM enrolled in the Montana Diabetes Prevention Program, 2008-2016.Achieved 7% weight lossat 4 monthsAchieved 5% weight lossat 4 monthsAdjusted Odds Ratio (95% CI)PAdjusted Odds Ratio (95% CI)PAge (years)60+0.82 (0.27-2.5)0.720.79 (0.27-2.32)0.6736-591.0Reference1.0ReferenceSexFemale1.(0.31-3.55)0.930.41 (0.13-1.33)0.14Male1.0Reference1.0ReferenceBaseline BMI (kg/m2)25.0-29.91.41 (0.29-6.93)0.690.69 (0.14-3.37)0.5330.0-34.91.04 (0.28-3.82)0.851.31 (0.39-4.47)0.5035.0+1.0Reference1.0ReferenceCore Self-monitored fat (weeks)14-165.67 (1.67-27.55)0.024.21 (1.07-16.57)0.027-132.07 (0.44-9.74)0.811.34 (0.39-4.63)0.410-61.0Reference1.0ReferencePhysical activity goalMet2.92 (0.86-9.88)0.082.76 (0.97-7.84)0.06Unmet1.0Reference1.0Reference*95% CI – Ninety-five percent confidence interval. Disclosure D. Carpenedo: None.S.M. Brokaw: None.S. Tysk: None.J. Fernandes: None.S.D. Helgerson: None.T.S. Harwell: None.