Abstract
Weight loss is a frequent clinical finding in Alzheimer's patients. Although it is obvious that in the final stage Alzheimer's patients lose weight, in the early stage of disease there are several hypotheses why Alzheimer's patients lose weight. The resting metabolic rate was not higher in Alzheimer's patients than in healthy elderly subjects. We investigated the weight changes in 28 patients from an early stage of Alzheimer's disease and compared with healthy control subjects for more than 3 years up to 12 years. Mean weight changes are similar (Alzheimer's patients -0.7±8.2 kg vs Control subjects -0.8±3.4kg). However Alzheimer's patients showed much exaggerated weight changes individually (Alzheimer's patients 75% vs Control subjects 43%), which was statistically significant. Another finding is that 32 % of Alzheimer's patients showed weight gain, which is greater than 14% of control subjects.
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