Abstract
use. 3 However, since the outcome was “changes in BP” along with the changes of body weight, we feel that this shortcoming did not affect the results in a meaningful way. Third, the duration of hypertension at baseline might be important to modulate BP changes through lifestyle interventions, because patients with an onset of hypertension close to baseline and mild vascular damage may be more responsive to BP reduction compared with those with long-lasting hypertension and more pronounced vascular damage. This is also the case for patients with and without overt cardiovascular disease, as well as for patients with hyperlipidaemia alone compared with those with hypertension or with the combined phenotype of hyperlipidemia and hypertension. Additional important confounders that could
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