Abstract
BackgroundMedical institutions worldwide have not reached a consensus on what surgery is the most advisable for pulmonary typical carcinoid (TC) patients at the localized stage. This research focuses on exploring whether wedge resection or segmental resection is the superior option.MethodsThe demographic and clinical information of 1,887 TC patients diagnosed at the localized stage from 2004 to 2015 was collected from the Surveillance, Epidemiology, and End Results (SEER) Program. Patient prognosis was evaluated by KM curves. The chi-square test was used to examine the variation between different groups that would be eliminated by propensity score matching (PSM). Univariate and multivariate Cox proportional hazard model analyses were used to evaluate prognostic values of relative factors.ResultsThe prognosis of TC was the most favorable for patients suffering from pulmonary squamous cell carcinoma (SCC), adenocarcinoma (ADC), and pulmonary carcinoids (PCs). The choice to have surgery, not the type of surgery chosen, was the most significant independent prognostic factor correlated with overall survival (OS) and lung cancer-special survival (LCSS). The prognostic result of the comparison between wedge resection and segmental resection was not statistically significant before or after PSM. In subgroup analysis, the inference still held.
Highlights
Typical carcinoid (TC) is one of four major pathological classifications of neuroendocrine tumor (NET) of the lung categorized by the World Health Organization (WHO)
Wedge resection is equal to segmental resection for pulmonary typical carcinoid patients at localized stage: a population-based analysis
The important discovery of this report is that wedge resection is likely to be equal to segmental resection for typical carcinoid (TC) patients at the localized stage
Summary
Typical carcinoid (TC) is one of four major pathological classifications of neuroendocrine tumor (NET) of the lung categorized by the World Health Organization (WHO). Wedge resection is equal to segmental resection for pulmonary typical carcinoid patients at localized stage: a population-based analysis. Surgery has been the main treatment for TC, the low-grade lung NET, at the localized stage (Wolin, 2015; Wolin, 2017). Medical institutions worldwide have not reached a consensus on what surgery is the most advisable for pulmonary typical carcinoid (TC) patients at the localized stage. The prognosis of TC was the most favorable for patients suffering from pulmonary squamous cell carcinoma (SCC), adenocarcinoma (ADC), and pulmonary carcinoids (PCs). The prognostic result of the comparison between wedge resection and segmental resection was not statistically significant before or after PSM.
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