Abstract
Wearable contact lenses which can monitor physiological parameters have attracted substantial interests due to the capability of direct detection of biomarkers contained in body fluids. However, previously reported contact lens sensors can only monitor a single analyte at a time. Furthermore, such ocular contact lenses generally obstruct the field of vision of the subject. Here, we developed a multifunctional contact lens sensor that alleviates some of these limitations since it was developed on an actual ocular contact lens. It was also designed to monitor glucose within tears, as well as intraocular pressure using the resistance and capacitance of the electronic device. Furthermore, in-vivo and in-vitro tests using a live rabbit and bovine eyeball demonstrated its reliable operation. Our developed contact lens sensor can measure the glucose level in tear fluid and intraocular pressure simultaneously but yet independently based on different electrical responses.
Highlights
Wearable contact lenses which can monitor physiological parameters have attracted substantial interests due to the capability of direct detection of biomarkers contained in body fluids
Even the most advanced contact lens sensors, rely on opaque electronic components constructed on lens-shaped plastic substrates with low oxygen permeability, instead of on actual soft hydrogel lenses, which can limit the safe operation of the devices on a live eye[14,15,16,17,18], as summarized in Supplementary Table 1
Resistance of the hybrid remains almost constant (DRo6%) even after 5,000 cycles of stretching (25% tensile strain) and relaxation, while the value increased to 20% at 10,000 cycles (Fig. 1f). These results suggest that the graphene-AgNW hybrid is a promising component of wearable electronics on soft contact lenses
Summary
Wearable contact lenses which can monitor physiological parameters have attracted substantial interests due to the capability of direct detection of biomarkers contained in body fluids. We report transparent and stretchable, multifunctional sensors on wearable soft contact lenses for the wireless detection of glucose and intraocular pressure with high-sensitivity. By integrating the components into a resistance (R), inductance (L) and capacitance (C) circuit operating at a radio frequency, we demonstrate realtime in-vivo glucose detection on a rabbit eye and in-vitro monitoring of intraocular pressure of a bovine eyeball wirelessly.
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