Wearable Fiber SPR Respiration Sensor Based on a LiBr-Doped Silk Fibroin Film.

Abstract

Respiration is essential for supporting human body functions. However, a biocompatible fiber respiration sensor has rarely been discussed. In this study, we propose a wearable fiber surface plasmon resonance (SPR) respiration sensor using a LiBr-doped silk fibroin (SF) film. The SPR sensor monitors respiration by responding to airway humidity variation during inhalation and exhalation. We fabricated the SPR respiration sensor by depositing the core of a plastic-clad optical fiber with a gold film and an SF-LiBr composite film. The SF-LiBr composite film can absorb water through the interaction between water molecules and hydrogen bonds linking fibroin chains. Thus, humidity variation can change the SF-LiBr composite film's refractive index (RI), altering the phase-matching condition of the surface plasmon polaritons and shifting the SPR spectral dip. In experiments, we test the effect of the LiBr doping ratio on humidity response and confirm that the SF-22.1 wt % LiBr sensor has balanced performances. The SF-22.1 wt % LiBr sensor has a broad sensing range of 35-99% relative humidity (RH), a reasonable overall sensitivity of -6.5 nm/% RH, a fast response time of 135 ms, a quick recovery time of 150 ms, good reversibility, and good repeatability, which is capable of tracking different respiration states and patterns. Finally, we encapsulate this sensor in a conventional nasal oxygen cannula for wearable respiration monitoring, proving that the sensor is suitable for high-sensitivity, real-time, and accurate respiration monitoring.