Abstract
BACKGROUND: A significant number of infants who respond favorably to inhaled nitric oxide (INO) therapy prove difficult to wean off INO. This INO dependence necessitates prolonged use of INO or, on occasion, the use of alternative treatments, such as extracorporeal membrane oxygenation (ECMO). We observed that infants who appeared to be INO dependent could, in fact, be successfully weaned if the FIO2 was increased briefly during the withdrawal of INO therapy.
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