Abstract
The maternal age-related fertility is closely associated with the quality of oocyte, the decline of aged oocyte quality predominate the prevalence of vital chromosomal abnormalities and poor development of embryos that inevitably resulting the failure of implantation or miscarriage. Cytoplast defect, for example, age-related accumulation of muted mtDNA, was believed the factor responsible for quality decline of aged human oocyte, however, in this study, we found that the weakness of karyoplast is the major factor to deteriorate quality of aged human MII oocyte.
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