Abstract

Multi-output regression seeks to borrow strength and leverage commonalities across different but related outputs in order to enhance learning and prediction accuracy. A fundamental assumption is that the output/group membership labels for all observations are known. This assumption is often violated in real applications. For instance, in healthcare data sets, sensitive attributes such as ethnicity are often missing or unreported. To this end, we introduce a weakly supervised multi-output model based on dependent Gaussian processes. Our approach is able to leverage data without complete group labels or possibly only prior belief on group memberships to enhance accuracy across all outputs. Through intensive simulations and case studies on insulin, testosterone and body fat data sets, we show that our model excels in multi-output settings with missing labels while being competitive in traditional fully labeled settings. We end by highlighting the possible use of our approach in fair inference and sequential decision making. History: Irad Ben-Gal served as the senior editor for this article. Funding: This research was supported in part by the National Science Foundation’s Cyber-Physical Systems (CPS) Program [Award 1931950]. Data Ethics & Reproducibility Note: The code capsule is available on Code Ocean at https://codeocean.com/capsule/2590027/tree/v1 and at https://doi.org/10.1287/ijds.2022.0018 .

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