Weak task synchronization of default mode network in task based paradigms

Abstract

The brain's Default mode network (DMN) is generally characterized by brain areas that gets deactivated upon the presentation of a wide variety of externally focused, attention demanding tasks. These areas also exhibit significant intra-DMN functional connectivity and significant negative functional connectivity with other brain areas, especially with attention networks, in both resting state and task conditions. Therefore, the DMN has been hypothesized to be involved in internally directed cognitive activities such as autobiographical recall of the past, future planning and mind wandering. Recent research has discovered the role of bottom-up attention in modulating the behaviour of DMN. We hypothesize that the de-engagement of the DMN regions upon the presentation of an externally-focused attention-demanding stimulus may not be strictly stimulus locked and may exhibit significant trial-to-trial as well as subject-to-subject variability. Due to the involvement of frontoparietal control network in modulating the anticorrelations between DMN and dorsal attention network (DAN), we expect the DMN regions to have lower inter-trial and inter-subject synchronization in their fMRI BOLD responses as compared to the bottom-up early-sensory task-positive regions. To test this hypothesis, we designed new statistical methods called Inter Trial Temporal Synchronization Analysis (IT-TSA) and Inter Subject TSA (IS-TSA) to analyse variability across trials and subjects respectively. We analysed four publicly available datasets (total 223 subjects) across seven tasks related to different cognitive modalities and found out that there is significantly low stimulus-locked synchronization across trials and subjects in the DMN regions as compared to early sensory task positive regions. Our study challenges the understanding of DMN as a strictly task-negative region and supports the recent findings that DMN acts as an active component associated with intrinsic processing which deactivates differentially and non-linearly across trials and subjects in the presence of extrinsic processes.