Abstract
A weak Brønsted base-promoted photoredox catalysis has been developed for the direct CH α-alkylation of heteroarenes with cyclic and acyclic ethers. The high efficiency of this strategy is demonstrated by the mild reaction conditions, broad substrate scope, economical reagents and high regioselectivity. With air as the sole oxidant, a set of alkylated heteroarenes were accessed smoothly. This strategy was also applied for late-stage functionalization of valuable vitamin E nicotinate and loratadine.
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