Abstract
Purpose: To investigate the effectiveness of highly conformal radiation modalities in conjunction with a patient setup correction method, Helical Tomotherapy (HT) was employed using the Helical Megavoltage CT (MVCT) scanner of the tomotherapy unit. Any discrepancy between the planned and delivered dose distributions would likely affect the clinical outcome. Method and Materials: The case of a head and neck cancer was used to evaluate the accuracy of dose delivery. The right parotid, left parotid and spinal cord are the primary organs at risk proximal to the target volume. MVCT images were taken before and after the patient setup correction. MVCT images of the patient were acquired daily. The three dose distributions (planned, with and without patient setup correction) were compared by using the complication‐free tumor control probability (P +) and the biologically effective uniform dose (BEUD) concepts. Results: For the computerized treatment plan, the maximum value of P + is 88.3%, the total control probability, P B is 97.3% and the total risk for complications, P I is 9.3%. For the delivered dose distribution without patient setup correction, the value of P + is 79.8% and the probabilities P B and P I are 83.6% and 3.8%, respectively. Finally, for the delivered dose distribution with patient setup correction in every fraction the value of P + is 87.2% and the probabilities P B and P I are 92.7% and 5.5%, respectively. The expected clinical effectiveness dropped by a ΔP + of 1.1% and 8.5% in the cases with and without patient setup correction. Conclusion: Highly conformal treatment plans can deliver higher doses to the target allowing for increased control rates for the same or a reduced risk for complications. The results show that the effectiveness of the applied dose distribution drops between the treatment plan and the dose delivery with and without patient setup correction.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
