Abstract
The Wiskott-Aldrich Syndrome Protein family Verprolin--homologous proteins (WAVEs), encoded by a metastasis promoter gene, play considerable roles in adhesion of immune cells, cell proliferation, migration and destruction of foreign agents by reactive oxygen species. These diverse functions have lead to the hypothesis that WAVE proteins have multi-functional roles in regulating cancer invasiveness, metastasis, development of tumor vasculature and angiogenesis. Differentials in expression of WAVE proteins are associated with a number of neoplasms include colorectal cancer, hepatocellular cancer, lung squamous cell carcinoma, human breast adenocarcinoma and prostate cancer. In this review we attempt to unify our knowledge regarding WAVE proteins, focusing on their potentials as diagnostic markers and molecular targets for cancer therapy.
Highlights
Cancer is one of the most dreadful diseases of the 20th century and the second leading cause of mortality worldwide
Differentials in expression of WAVE proteins are associated with a number of neoplasms include colorectal cancer, hepatocellular cancer, lung squamous cell carcinoma, human breast adenocarcinoma and prostate cancer
The more effective target for anticancer drugs, it is essential to interaction of WAVE2 with HSPC300 (Haematopoietic discuss WASPs and WAVE proteins in greater detail and stem/progenitor cell protein 300) increases metastatic its relevance with cancer invasion (Kurisu and Takenawa, potential of lung squamous cell carcinoma (Cai et al, 2009)
Summary
Cancer is one of the most dreadful diseases of the 20th century and the second leading cause of mortality worldwide. These diverse functions have lead to the hypothesis that WAVE proteins have multi-functional roles in regulating cancer invasiveness, metastasis, development of tumor vasculature and angiogenesis. In this review we discuss the roles of WAVE proteins during tumor progression and as a potential molecular target for cancer therapy (Derry et al, 1994; Miki et al, 1996; Miki et al, 1998; Kurisu et al, 2009).
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