Abstract
A series of water-soluble platinum(II) complexes of reduced amino acid Schiff bases were synthesized as potential anticancer agents and characterized by 1H NMR, EA, MS, IR, and molar conductivity. These compounds were tested for their DNA interaction with salmon sperm DNA, and their in vitro anticancer activities have been validated against HL-60, KB, BGC-823, and Bel-7402 cell lines by the MTT assay. The cytotoxicity of one complex (5g) is better than that of cisplatin against BGC-823 and HL-60 cell lines, and show close cytotoxic effect against Bel-7402 cell line.
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