Abstract
AbstractPerylene diimides (PDIs), a well‐studied class of organic dyes, have a strong tendency to self‐aggregate in water, thus greatly restricting their phototheranostic applications. Herein, we report a water‐soluble PDI cyclophane “Gemini Box” (GBox‐14+), consisting of a central PDI chromophore enclosed by double‐sided cationic molecular straps. Owing to the effective spatial isolation, the chromophore self‐aggregation can be completely eliminated, even in a concentrated aqueous solution up to 2 mM. To our knowledge,GBox‐14+represents an interesting example of a fluorescent PDI cyclophane in water, capable of being employed for lysosome‐targetable live‐cell imaging. More importantly, the highly concentrated aqueous solution of PDI radical anion can be significantly stabilized byGBox‐14+to exhibit an excellent near‐infrared photothermal effect, which was further exploited for efficient and selective antibacterial applications. This work provides a new access to water‐soluble non‐aggregated organic dyes and promotes their potential biomedical applications.
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