Abstract
Here we provide, at least to our knowledge, the first evidence that aripiprazole (APPZ) in the water blunts the stress response of exposed fish in a concentration ten times lower than the concentration detected in the environment. Although the mechanism of APPZ in the neuroendocrine axis is not yet determined, our results highlight that the presence of APPZ residues in the environment may interfere with the stress responses in fish. Since an adequate stress response is crucial to restore fish homeostasis after stressors, fish with impaired stress response may have trouble to cope with natural and/or imposed stressors with consequences to their welfare and survival.
Highlights
We provide, at least to our knowledge, the first evidence that aripiprazole (APPZ) in the water blunts the stress response of exposed fish in a concentration ten times lower than the concentration detected in the environment
The consumption of antipsychotic drugs has been growing gradually, especially due to the increasing the number of diagnostics of psychotic disorders in recent decades[1]
Our hypothesis is that APPZ has a dopaminergic stabilizer effect[20], since it is a partial agonist of dopamine receptors[30], and tends to buffer the effects of endogenous dopamine[31]
Summary
At least to our knowledge, the first evidence that aripiprazole (APPZ) in the water blunts the stress response of exposed fish in a concentration ten times lower than the concentration detected in the environment. The consumption of antipsychotic drugs has been growing gradually, especially due to the increasing the number of diagnostics of psychotic disorders in recent decades[1]. These drugs induce serious extrapyramidal effects in patients who are treated in a continuous and prolonged manner[2]. Due to its safety and lower incidence of unwanted side effects, the prescription of APPZ is increasing to replace classical antipsychotics. This increased use justify the concern about the accumulation of APPZ residues in wastewater and, potential negative effects in non-target organisms such as fish. Here we describe, for the first time, the effects of different concentrations of APPZ on the hypothalamic-pituitary-interrenal (HPI) axis in adult zebrafish
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