Abstract
AbstractCombination of advantages of ferrocenyl compounds and multifunctional dendrimer scaffold afforded a water‐soluble well‐defined bifunctional dendrimer with polyamide backbone and thirty two termini: eighteen carboxylic acid groups and eighteen triazolylferrocenyl moieties. The structure of the new dendrimer was thoroughly characterized by nuclear magnetic resonance (NMR) spectroscopy, absorbance spectroscopy in the UV‐vis, and MALDI‐TOF mass spectrometry. The MALDI‐TOF spectrum of the final dendrimer showed the [M]2+ ion peak at 4820.1 m/z unambiguously confirming the successful synthesis of the water‐soluble well‐defined bifunctional dendrimer. The cytotoxicity of the well‐defined bifunctional triazolylferrocenyl dendrimer 4 was evaluated against MCF‐7 (breast adenocarcinoma), HeLa (cervical cancer), PC3 (prostate adenocarcinoma), Caco‐2 (colorectal cancer), and PNT2 (normal prostate cells) cell lines. The cytotoxicity assays showed that the dendrimer exhibits moderate anticancer activity and targets cancer cells selectively over normal cells.
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