Abstract
The design and synthesis of new near infrared (NIR) biocompatible dyes have been of great interest over the last years. Herein, the synthesis of two new water soluble NIR dyes is reported: a PEGylated (PEG = polyethyleneglycol) fluorinated bacteriochlorin [5,10,15,20-tetrakis(4-PEG500-2,3,5,6-fluorophenyl)bacteriochlorin], prepared in a straightforward synthetic strategy involving a solventless reduction; and an improved strategy to prepare a PEGylated tetra-substituted free-base phthalocyanine [2(3),9(10),16(17),23(24)-tetrakis(4-PEG200)phthalocyanine], obtained in 52% overall yield, from the PEGylated phthalonitrile. Photophysical characterization and photostability studies were performed, where both dyes showed favorable photostability and the PEGylated fluorinated bacteriochlorin presented good singlet oxygen quantum yield, showing potential to use as a photosensitizer for PDT (photodynamic therapy). Additionally, the free-base PEGylated phthalocyanine displayed reasonably high Stokes shift, suggesting high potential to use in optical imaging.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
