Abstract
The sensing of carboxylesterases (CESs) activity in living systems is of great importance for drug design and biomedical research. Herein, water-soluble AIE-active fluorescent organic nanoparticles (2B3OTs) containing hydrophilic lactose and hydrophobic BODIPY-conjugated tetraphenylethene moieties were rationally designed for ratiometrically fluorescent sensing of CESs with the meso-ester BODIPY as the recognition unit. 2B3OTs were cell membrane permeable and successfully applied to detect the real activities of endogenous CESs in living cells. More importantly, 2B3OTs could preferentially recognize hepatoma cells rather than normal liver cells, since the lactose is an efficient ligand for asialoglycoprotein receptors which are over expressed in tumor liver cells. It is first time that water-soluble AIE-active fluorescence organic nanoparticle were designed and utilized for real-time sensing of CESs activities in living cells.
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