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Abstract
Moringa oleifera, a plant widely used in traditional medicine as well as for water purification, contains a lectin on its seeds named WSMoL which modulates several immune characteristics and has shown cardiac safe properties. Here, we tested the hypothesis that WSMoL is able to recover fasting glucose levels and to improve the cardiac left ventricular (LV) function in a type 2 diabetes mellitus (T2DM) mice model. T2DM was induced in adult C57BL/6 mice by combining a high fat diet and low doses of Streptozotocin. Mice were randomly divided in two groups: i. received WSMoL for 21 consecutive days by gavage (T2DM + WSMoL) and ii. received saline solution (T2DM). Metabolic parameters and LV function were assessed. WSMoL was able to reduce fasting blood glucose levels in T2DM mice after 2 weeks of treatment, when compared to T2DM untreated group. Regarding to cardiac LV function, the T2DM + WSMoL group depicted ejection fraction values comparable to non-diabetic group. Our results show: i. WSMoL treatment presented a potent hypoglycemic effect decreasing insulin resistance and ii. WSMoL was able to improve cardiac LV ejection fraction. Collectively, the results presented here show WSMoL as a potential hypoglycemic agent to be tested in T2DM patients.
Highlights
Moringa oleifera Lamarck (MO - Moringaceae) is a tree that, even though is native from southern Himalayan region, it is widely found in northeastern Brazilian regions (Coelho et al 2009, Moura et al 2015, 2017, Ferreira et al 2011, Rodriguez-de-Yurre et al 2019, Santos et al 2015)
After 9 weeks, the combination of HFD and two low STZ injections, was not able to induce differences on body weight among groups (Fig. 1a). Both epidydimal and retroperitoneal fat were higher in the type 2 diabetes mellitus (T2DM) treated and untreated WSMoL groups, when compared to control group (CTRL) non-diabetic mice (Fig. 1b and 1c)
Several reports suggest that the intake of water containing seeds of Moringa oleifera improves the glycemic levels in animals and diabetic patients (Divi et al 2012, Gupta et al 2012, Efiong et al 2013, Kumari 2010, Al-Malki & El-Rabey 2015)
Summary
Moringa oleifera Lamarck (MO - Moringaceae) is a tree that, even though is native from southern Himalayan region, it is widely found in northeastern Brazilian regions (Coelho et al 2009, Moura et al 2015, 2017, Ferreira et al 2011, Rodriguez-de-Yurre et al 2019, Santos et al 2015) It has been especially used for its nutritional content, and has been widely used in traditional medicine for its vast medicinal properties (Ferreira et al 2011, Santos et al 2015, Hassan & Ibrahim 2013). Seeds have been used to treat respiratory diseases such as asthma, and a clinical study using seed powder showed significant improvement in pulmonary function (Agrawal & Mehta 2008) In this regard, several investigations in animal
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