Abstract
The permeation of water through thin, solvent-cast poly(ortho ester) films was determined as a function of the polymer weight-average molecular weight (7,800 to 104,200). A 2-chambered diffusion cell was employed using tritiated water (HTO) and H 2O 18 as tracers. The permeability coefficients (2.5 to 5.0×10 −10 cm 2/sec; not statistically significantly different; 37°C) were independent of the polymer molecular weight over the range 29,400 to 104,200. A poly(ortho ester) film with a weight-average molecular weight of 7,800 exhibited a significantly larger water permeability coefficient (24.6×10 −10 cm 2/sec; 37°C). These results were consistent with an increased hydrophilicity of the low molecular weight poly(ortho ester) film and predict an accelerated rate of hydrolytic degradation as the polymer molecular weight falls below a limiting value.
Published Version
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