Water Molecules: A Closer Look at Their Behavior at Protein-Protein Interfaces and Their Contributions to the Docked Model of Pyridoxal Kinase - Serine Hydroxymethyltransferase Complex

Abstract

xii Chapter Page 1 General Introduction 1 1.1 Role of water in protein-protein complex interface 1 1.1.1 Water the vivacious molecule 1 1.1.2 Different roles of water in biological processes 1 1.1.2.1 Role of water molecules in protein-ligand binding... 2 1.1.2.2 Role of water molecules in protein-DNA binding.... 3 1.1.2.3 Role of water molecules in protein-protein binding.. 4 1.2 Pyridoxal kinase (PLK) – Serine hydroxymethyltransferase (SHMT) complex 8 1.2.1 Pyridoxal 5‟-Phosphate (PLP)-dependent enzymes 8 1.2.2 Pyridoxal Kinase (PLK) 8 1.2.3 Pyridoxal 5‟-Phosphate (PLP) metabolic pathways 10 1.2.4 Mechanism of transfer of PLP from PLK to SHMT and other