Abstract

An efficient multicomponent approach has been developed in the environmentally green aqueous medium for synthesis of substituted polyfunctionalized pyrazoles. The simple and readily available aldehydes, malononitrile and phenylhydrazines substrates afforded polysubstituted imidazoles (15 examples) up to 96 % yield. The polyethylene glycol is playing the dual role of solvent and promoter with water in this reaction catalyzed by ceric ammonium nitrate.

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