Abstract
Normal Wistar rats, normal and kininogen-deficient Brown Norway rats were kept at ambiant temperatures of 26 degrees C, 36 degrees C or 40 degrees C for 3 to 5 hours. Their colonic temperatures and body weights were measured. At 26 degrees C, the changes in these parameters were similar in the three strains. At 36 degrees C, body weight loss was increased more in normal rats than in kininogen-deficient rats. At 40 degrees C, body temperature increased more quickly and body weight loss was less enhanced in kininogen-deficient rats than in normal rats. The water content of muscles was less reduced in kininogen-deficient rats than in normal rats. HOE 140, a bradykinin antagonist, reduced the weight loss of Wistar rats kept at 36 degrees C and 40 degrees C. Atropine or removal of submaxillary glands increased colonic temperature and reduced the weight loss of Wistar rats at 36 degrees C and 40 degrees C. HOE 140 did not modify the reduction of weight loss induced by atropine but increased colonic temperatures and decreased thermal tolerance of atropinized Wistar rats at 36 degrees C. These results indicate that the kallikrein-kinin system plays a role in salivary secretion and in heat exchange during a heat exposure.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Archives internationales de physiologie, de biochimie et de biophysique
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
