Abstract
AbstractThe solubilization of water and toxoid solutions in oils by non-ionic surface-active agents has been examined. Water-in-oil solubilized adjuvant formulations of vaccines containing Clostridium welchii type D toxoid as antigen have been tested in laboratory animals. The antitoxin titres in rabbit serum induced by the most successful formulation were as high 14 weeks after a single dose, as the peak titres after two doses of a simple aluminium hydroxide adsorbed vaccine. The vaccines are clear and of low viscosity which facilitates accurate measurement and handling by syringe.
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