Abstract
From the evolutionary perspective, water immersion skin wrinkling (WISW) is the perceived water drainage to enhance grip in wet conditions. In modern medicine, it is a noninvasive test of limb sympathetic function and can be used to assess peripheral neuropathy. WISW occurs as sympathetically-mediated contraction of subcutaneous glomus bodies after perturbation of ion concentration in palmar sweat glands. This phenomenon has not been studied well and it is not clear if common demographic variations (e.g. age, sex, and adiposity) that impact overall cardio-autonomic health status also affect WISW. PURPOSE: The purpose of the present study is to determine if peak WISW is modulated by age, sex, and body adiposity, additionally, we addressed if this phenomenon is associated with osmotic reactions or edema. METHODS: So far 12 apparently healthy adults (5 females) aged 34.5±17.6 years were studied. Participants hands were submersed in 40°C water for 30 minutes with degree of wrinkling being assessed via 5-point scale (0 to 4) at 10-minute intervals. Final ratings for digits 2-5 were summed and used to determine peak WISW with a score of 16 being the highest and 0 being the lowest possible scores. Additionally, hand and forearm volume were measured via water displacement before and after submersion to quantify hand volume expansion. RESULTS: Peak WISW ranged from 5 to 16 with the mean (±SEM) score of 13.2±1.3. Peak WISW was moderately correlated with age (r=-0.54), BMI (r=-0.39), body fat percentage (r=-0.51). Males demonstrated a greater degree of WISW with a mean rating of 16 compared with females with a mean rating of 9 (p<0.01). Hand and forearm volume did not change with water immersion (497±29 vs. 500±30 ml). Changes in hand and forearm volume were not associated with peak WISW (r=-0.03). CONCLUSION: The preliminary results indicate that water immersion skin wrinkling varies widely with age, sex, and body adiposity and is not associated with edema or osmotic reactions.
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