Water-Compatible Fluorescent Molecularly Imprinted Polymers.

Abstract

Preparation of molecularly imprinted polymers (MIPs) capable of directly and selectively recognizing small organic analytes in aqueous samples (particularly in the undiluted complex biological samples) is described. Such water-compatible MIPs can be readily obtained by the controlled grafting of appropriate hydrophilic polymer brushes onto the MIP particle surfaces. Two types of synthetic approaches (i.e., "two-step approach" and "one-step approach") for preparing complex biological sample-compatible hydrophilic fluorescent MIP nanoparticles and their applications for direct, selective, sensitive, and accurate optosensing of an antibiotic (i.e., tetracycline (Tc)) in the undiluted pure bovine/porcine serums are presented.