Water as Green Solvent for the Carbon-Nitrogen Bond Formation

Abstract

Background: Edifice of C–N bond attained a very impressive position in organic synthesis as it unlocks avenues for offering nitrogen in organic molecules. As we know that water has emerged as a versatile solvent for the synthesis of a variety of organic compounds. Moreover, in accordance to green chemistry, using a very optimistic environment friendly solvent is the main concern for synthetic chemists. Thus, water always comes first in mind as a solvent of choice in appeal to environmentally benign solvents. The inertness of water and its property to dissolve maximum number of compounds, its abundant sources in nature, further embrace it as a crown. Recent years witnessed advancement in green chemistry, further forcing the organic chemists for selecting the solvent for the reaction, which will be less perilous for the mother nature. Material and methods: Thus, in present time, many reports have been available in literature, wherein water is embellished for performing organic reactions and synthesis of an ample amount of heterocyclic compounds. Therefore, there is a need of time to compile the latest research articles wherein water has been working as solvent to focus on C-N bond forming reactions. As among the heterocyclics, the compounds with carbon nitrogen bonds also possess a significant place due to their importance in medicinal and material science. Results: Thus, the present draft perceived some current and most impressive carbon-nitrogen bond forming reactions exploring water as a reaction media. Moreover, we have made efforts to include more application parts and synthesis of important biological nitrogen containing heterocyclic to be included in the present study. Conclusion: Thus, we have tried here to compile all the recent reports of C-N bond foration in water, which help the reviewers to have insight in to C-N bond forming reactions employing water as reaction media.