Abstract
Proteins called cytokines that are secreted by cells within the lymph nodes are often used as drugs to manipulate immune responses. But something so basic as how these proteins travel through lymph node tissue is poorly understood. At last week’s ACS national meeting in Washington, D.C., in a Division of Analytical Chemistry symposium, Ashley E. Ross of the University of Cincinnati described a microfluidic platform for studying the diffusion of cytokines through mouse lymph node tissue. She did the work while still a postdoc with Rebecca R. Pompano at the University of Virginia. The device is a simplified version of one they published earlier this year (Analyst 2017, DOI: 10.1039/c6an02042a). Ross studied the diffusion of fluorescently labeled cytokines in parts of the lymph node and measured how it differed in normal and inflamed tissue. These measurements enabled Ross to calculate diffusion coefficients for various cytokines through the tissue. By combining
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