Abstract
Watching Genes Loop the Loop
Highlights
Most cells of a given species contain essentially the same complement of genes, yet individual genetically identical cells can assume dramatically different appearances and behaviours
The dormant lysogenic phase can be perpetuated stably for many bacterial generations, and is maintained by the binding of the lambda repressor to the phage genome. This is where it emerged that genes aren’t only regulated by the binding of proteins to sites in their immediate vicinity, as is the case of the simple lac operon
The lambda repressor molecules bind to two separate regions in the phage genome that are 2.3 kilobases apart
Summary
Most cells of a given species contain essentially the same complement of genes, yet individual genetically identical cells can assume dramatically different appearances and behaviours. This is achieved largely by the regulation of the transcription of individual genes, orchestrated by the specific binding of proteins to nearby sites in the genome—a principle first recognised 50 years ago by Francois Jacob (who just died this April) and Jacques Monod from their work on the paradigmatic lac operon in Escherichia coli.
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