Wasserstein-GAN-based noise reduction for preserving anatomical structures in low-dose CT

Abstract

The purpose of low-dose computed tomography (LDCT) is to reduce patient's radiation dose. However, LDCT imaging often suffers from low image quality due to computed tomography (CT) noise patterns. While conventional methods such as iterative reconstruction and image processing have been studied to address this issue, their clinical application remains limited due to the degradation of critical anatomical structures. Recently, deep-learning-based noise reduction approaches have shown promising results in improving the image quality of LDCT. Particularly, generative adversarial network (GAN)-based noise reduction methods have produced outstanding results, approaching the quality of normal-dose CT (NDCT) images. In this study, we propose a hybrid framework based on Wasserstein-GAN with the non-subsampled contourlet transform for enhanced noise reduction in LDCT. The aim is to meticulously address CT noise patterns and generate CT images similar to NDCT. We implemented the proposed algorithm and conducted an experiment using clinical abdominal CT datasets to demonstrate its feasibility. According to our results, the proposed method effectively reduced noise components in LDCT images while preserving the anatomical structures of NDCT. This was confirmed through both qualitative and quantitative evaluations. The implications of our findings for clinical practice are significant, as the proposed method can improve the accuracy of LDCT and reduce radiation dose to patients, ultimately enhancing patient safety.