Abstract
Two antigens of human wart tissue, a nuclear and a cell surface antigen, were isolated from whole tissue homogenates by elution from antibody-Sepharose immunoadsorbents. Neither antigen was a structural component of purified human papilloma virus. The antigens were detected by immunofluorescence in warts, squamous cell carcinomas, fetal skin, and psoriatic epidermis, but not in normal skin or basal cell carcinomas. They could be detected in concentrated extracts of normal skin by agar gel diffusion. The antigens belong to the growing class of substances that are readily detected in tumors and in fetal tissues, but are present only in minute quantities in normal adult tissue.
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