Abstract
Warm cells were identified by Fura-PE3-based microfluorimetry of Ca 2+ in cultured dorsal root ganglion (DRG) neurons. In response to a physiologically relevant stimulus temperature (43°C), a subpopulation of small DRG neurons from new born rats increased the intracellular Ca 2+ concentration ([Ca 2+] i). Seven percent of the cells responded to the warm stimulus. The stimulus evoked elevation in [Ca 2+] i from 52.5±9.5 nM (mean±S.D., n=18) to 171.0±15.6 nM in cells between 15 and 25 μm in diameter. The depletion of extracellular Ca 2+ diminished the Ca 2+ elevation. The Na +-free condition also diminished the response. We concluded that the heat stimulation opens nonselective cation channels in putative warm cells from DRG neurons.
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