Abstract
The mechanism of the fluorescence quenching of the CQDs by warfarin was determined and based on this study a simple, low cost and highly sensitive nanosensor was developed for determination of Warfarin in plasma samples. The carbon quantum dots with 3.5µs lifetime (halflife of 2.4µs) were synthesized by hydrothermal method and characterized. The fluorescence rate constant of 4.5 × 104s-1 and quenching rate constant of 6.18 × 104s-1 (from 10μM warfarin that result in 17% lifetime reduction) was calculated. High quenching efficiency results in 21.63 L mmol-1 Stern-Volmer constant and the study of pH and temperature also confirm the dynamic quenching mechanism. The second order rate constant of 6.18 × 104 L mmol-1s-1 was obtained for collisions between CQDs and warfarin. Based on this mechanism, a simple, low cost and very sensitive warfarin nanosensor was developed with calibration sensitivity of 21.63 L mmol-1, working range of 0.10 - 12.00μM and detection limit of 0.01μM.
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