Warfarin and aspirin in the prevention and treatment of portal vein thrombosis after modified laparoscopic splenectomy combined with cardiac peripheral vascular disconnection

Abstract

Objective To investigate the clinical effect of warfarin and aspirin on prevention and treatment of portal vein thrombosis after modified laparoscopic splenectomy combined with cardiac peripheral vascular disconnection. Methods From August 2013 to June 2015, 62 patients with portal hypertension were selected. According to the order of admission, they were divided into study group and control group, with 31 cases in each group. The study group was treated with warfarin, and the control group was treated with aspirin. The incidences of portal venous system thrombosis at different time segment (1 week, 1 month, 3 months after operation) international normalized ratio (INR) changes before operation and at different time segment (1 week, 1 month, 3 months after operation), platelet count (PLT) and prothrombin time (PT) changes at different time segment (1, 3, 5 d after operation), and the portal vein blood flow velocity on the 7th day after operation were compared. Results The incidence of portal vein thrombosis at 1 week after operation in the study group was 29.03%, and that in the control group was 32.26%, the difference was not significant (P>0.05). The incidences of portal vein thrombosis at 1 month and 3 months after operation in the study group (16.13%, 9.68%) were significantly lower than those of the control group (38.71%, 35.48%), the differences were significant (P 0.05). The INR at 1 week, 1 month and 3 months after operation in the study group were significantly higher than those in the control group, and the differences were significant (P 0.05). Conclusions The effect of warfarin and aspirin on the prevention and treatment of modified laparoscopic splenectomy combined with cardiac peripheral vascular disconnection of portal vein thrombosis is exact, it can effectively inhibit the generation of prothrombin and other coagulation factors, and reduce the incidence of portal vein thrombosis, with the promotion value. Key words: Warfarin; Aspirin; Modified laparoscopic splenectomy; Cardiac peripheral vascular amputation; Portal venous system thrombosis