Abstract
Wanted: A New Model for Glucocorticoid Receptor Transactivation and Transrepression
Highlights
Glucocorticoid receptor (GR) is a transcription factor that is almost ubiquitous in vertebrate cells
As one of the cellular receptors for steroid hormones of the glucocorticoid (GC) family, which are well known for their anti-inflammatory properties in clinical applications, the regulation of GR activity has been the focus of intense study
Upon binding GC, GR translocates from the cytoplasm to the nucleus, where it may either bind to and activate transcription from gene promoters or interact with other transcription factors to alter their function
Summary
Glucocorticoid receptor (GR) is a transcription factor that is almost ubiquitous in vertebrate cells. Wanted: A New Model for Glucocorticoid Receptor Transactivation and Transrepression Upon binding GC, GR translocates from the cytoplasm to the nucleus, where it may either bind to and activate transcription from gene promoters (transactivation) or interact with other transcription factors to alter their function (transrepression). Several groups are searching for GR ligands that can separate GR’s transactivation and transrepression activities.
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