Waldenstrom Macroglobulinemia, a Rare Hematological Malignancy:

Abstract

Waldenstrom macroglobulinemia is a rare hematological malignancy which accounts for only about 1% of the diagnosis. It is unique among B cell malignancies that usually produce a large amount of immunoglobulin M(IgM). Some patients may be symptomatic commonly fatigued due to anemia, bleeding or neurologic complaints, while others may be asymptomatic. There is a greater proportion of men and are diagnosed in their mid-60s. Here we report a case of a 58-yearold male who presented with increased fatigability. Routine blood investigation showed anemia with raised ESR and reversal of albumin globulin ratio.Bone marrow study was done to rule out multiple myeloma,which showed hypercellular marrow predominantly composed of atypical mononuclear cells with variable morphology from lymphocytes to plasma cells.Serum electrophoresis was adviced which revealed elevated serum