Waist Circumference Indexed by the Square Root of Height and Waist to Height Ratio Provide Strong Prediction of Low eGFR (< 60ml/Min/1.73m <sup>2</sup>) in Elderly Taiwan Females

Abstract

Background: Screening and management of risk factors of can prevent low estimated glomerular filtration rate(eGFR). The aim of the current study is to investigate the most powerful predictor of obesity related health outcomes of low eGFR in elderly Taiwan women. Methods: Measurements from 1106 elderly female Taiwanese participants in the geriatric health examination in a community were used from 2007 until 2008. Pearson correlation of indices of obesity was determined. Multivariable logistic regression modeling and comparisons of area under the receiver operating characteristic curves with bootstrap validation to assess the performance of all indices in the prediction of Low eGFR (< 60ml/min/1.73m2) were used. Findings: While compared with area under the receiver operating characteristic curves and adjusted by significant variables and validated by bootstrap, waist circumference indexed by the square root of height (WHt0.5R) and waist to height ratio (WHtR) showed significantly powerful prediction of low eGFR in the elderly female cohort. The analysis of trends of odd ratios of WHt0.5R and WHtR revealed quartile 4 significantly at more risk of ow eGFR than quartile 1. Interpretation: Waist circumference indexed by the square root of height and waist to height ratio are better than other adiposity indexes in the prediction of elderly women at more high risk of low eGFR, while quartile 4 of these indices of central obesity are convenient, safe and cheap markers and justified for use in intervention of obesity in the Taiwan elderly women cohort. Funding Statement: We did not receive funding from University, grants, and company. Declaration of Interests: The authors state: There are no competing interests. Ethics Approval Statement: The study was approved by the Department of Education and Research of Taipei City Hospital and the Institutional Review Board of the Taipei City Hospital (TCHIRB-1010614-E) in 2012.